Shanghai Shucan Industrial Co.,Ltd
|Place of Origin:||China|
|Minimum Order Quantity:||10gram|
|Packaging Details:||discreet and safe foil bag or tin|
|Delivery Time:||Within 12hours after payment|
|Payment Terms:||West Union, T/T, Money Gram.,Bitcorn and bank transfer|
|Supply Ability:||5000kilogram per month|
selective androgen receptor modulator,
Product Name: YK11/ YK-11
Full Name: (17a,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna- 4,20-diene-21-carboxylic Acid Methyl Ester
Synonyms: (17a,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna- 4,20-diene-21-carboxylic Acid Methyl Ester;YK11 ((17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-
CAS: 431579-34-9; 366508-78-3
Standard: In-house Standard
Appearance: White powder
Purity: 98.6 %
Shelf life: 2 years
Dosage: Daily dosage of YK11 is 4 mg once a day for hardcore users max 8 mg
SARMS or selective androgen receptor modulators are well-known for giving the same muscle growth results as anabolic steroids but without the negative side effects that comes with the latter. Japanese scientists are doing an experiment on a new SARM known as YK11 which is said to be the strongest amongst all, even more potent than classic steroids such as DHT. YK11 is believed to be a SARM and produce the effect of myostatin at the same time.
YK11 is a potent and specific synthetic REV-ERB. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of YK11 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice.
The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with YK11 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
Certificate Of Analysis:
|Specific Rotation||+39°~ +43°||+40.2°|
|Organic Volatile Impurities||Conform||Conform|
|Loss On Drying||≤0.50%||0.27%|
|Residue On Ignition||≤0.10%||0.015%|
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