Anti Inflammatory Anesthesia Phenacetin Local Anesthetic Drugs Cas 62-44-2 Pain Relieving Pharma Drug

Anti Inflammatory Local Anesthesia Phenacetin Drug Cas 62-44-2 Pain Relieving

Phenacetin

English Synonyms: 1-acetamido-4-ethoxybenzene; para-Acetophenetidide; p-acetophenetidine;
p-acetophenetide; p-acetphenetidin; paracetophentidin; p-Ethoxyacetanilide; 4'-ethoxyacetanilide;
Para-phenaceti; acet-p-phenalide; acet- p-phenetidin; aceto-para-phenalide; aceto-para-phenetidide; Acetophenetidine; acetophenetin; acetylphenetidin; coricidin; empirin compound;
N- (4-ethoxyphenyl) -acetamide; N-Acetyl-4-ethoxyaniline; N-acetyl-p -phenetidine; phenacet; phenacitin; phenazetin; Phorazetim; pyraphen
CAS: 62-44-2
EINECS Number: 200-533-0
Formula: C10H13NO2
MW: 179.2157
Density: 1.099g / cm3
Melting point: 133-138 ºC
Boiling point: 355.1 ° C at 760 mmHg
Flash Point: 168.5 ° C
Water-soluble: 0.076 g / 100 mL
Vapor Pressure: 3.21E-05mmHg at 25 ° C
Uses:Anti-inflammatory drugs
Assay:99%
Appearance: White or almost white crystalline powder

Descriptions:

Phenacetin is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which

include increased risk of certain cancers and kidney damage. It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on phenacetin.

Applications:

Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an
"A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but

with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was

also reformulated without phenaceti. Paracetamol is a metabolite of phenacetiwith similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.

Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.

Due to low cost phenacetin is used for research into the physical and refractive properties of crystals.
It is an ideal compound for this type of research

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